Culture shapes reasoning, values, prioritization, and strategic decision-making, yet large language models (LLMs) often exhibit cultural biases that misalign with target populations. As LLMs are increasingly used for strategic decision-making, policy support, and document engineering tasks such as summarization, categorization, and compliance-oriented auditing, improving cultural alignment is important for ensuring that downstream analyses and recommendations reflect target-population value profiles rather than default model priors. Previous work introduced a survey-grounded cultural alignment framework and showed that culture-specific prompting can reduce misalignment, but it primarily evaluated proprietary models and relied on manual prompt engineering. In this paper, we validate and extend that framework by reproducing its social sciences survey based projection and distance metrics on open-weight LLMs, testing whether the same cultural skew and benefits of culture conditioning persist outside closed LLM systems. Building on this foundation, we introduce use of prompt programming with DSPy for this problem-treating prompts as modular, optimizable programs-to systematically tune cultural conditioning by optimizing against cultural-distance objectives. In our experiments, we show that prompt optimization often improves upon cultural prompt engineering, suggesting prompt compilation with DSPy can provide a more stable and transferable route to culturally aligned LLM responses.

Artificial intelligence (AI) is reshaping how research is conceived, conducted, and communicated across fields from chemistry to biomedicine. This commentary examines how AI is transforming the research workflow. AI systems now help researchers manage the information deluge, filtering the literature, surfacing cross-disciplinary links for ideas and collaborations, generating hypotheses, and designing and executing experiments. These developments mark a shift from AI as a mere computational tool to AI as an active collaborator in science. Yet this transformation demands thoughtful integration and governance. We argue that at this time AI must augment but not replace human judgment in academic workflows such as peer review, ethical evaluation, and validation of results. This paper calls for the deliberate adoption of AI within the scientific practice through policies that promote transparency, reproducibility, and accountability.

In recent years, Large Language Models (LLMs) have demonstrated remarkable capabilities across a wide range of natural language processing (NLP) tasks, such as question-answering, sentiment analysis, text summarization, and machine translation. However, the ever-growing complexity of LLMs demands immense computational resources, hindering the broader research and application of these models. To address this, various parameter-efficient fine-tuning strategies, such as Low-Rank Approximation (LoRA) and Adapters, have been developed. Despite their potential, these methods often face limitations in compressibility. Specifically, LoRA struggles to scale effectively with the increasing number of trainable parameters in modern large scale LLMs. Additionally, Low-Rank Economic Tensor-Train Adaptation (LoRETTA), which utilizes tensor train decomposition, has not yet achieved the level of compression necessary for fine-tuning very large scale models with limited resources. This paper introduces Tensor Train Low-Rank Approximation (TT-LoRA), a novel parameter-efficient fine-tuning (PEFT) approach that extends LoRETTA with optimized tensor train (TT) decomposition integration. By eliminating Adapters and traditional LoRA-based structures, TT-LoRA achieves greater model compression without compromising downstream task performance, along with reduced inference latency and computational overhead. We conduct an exhaustive parameter search to establish benchmarks that highlight the trade-off between model compression and performance. Our results demonstrate significant compression of LLMs while maintaining comparable performance to larger models, facilitating their deployment on resource-constraint platforms.